Targeting the sarcomere to correct muscle function
Various human diseases can disrupt the balance between muscle contraction and
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …
Heart failure with preserved ejection fraction: The pathophysiological mechanisms behind the clinical phenotypes and the therapeutic approach
Heart failure (HF) with preserved ejection fraction (HFpEF) is an increasingly frequent form
and is estimated to be the dominant form of HF. On the other hand, HFpEF is a syndrome …
and is estimated to be the dominant form of HF. On the other hand, HFpEF is a syndrome …
Optogenetic control of cellular forces and mechanotransduction
Contractile forces are the end effectors of cell migration, division, morphogenesis, wound
healing and cancer invasion. Here we report optogenetic tools to upregulate and …
healing and cancer invasion. Here we report optogenetic tools to upregulate and …
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
The design of compounds that can discriminate between closely related target proteins
remains a central challenge in drug discovery. Specific therapeutics targeting the highly …
remains a central challenge in drug discovery. Specific therapeutics targeting the highly …
Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation
E Rozbicki, M Chuai, AI Karjalainen, F Song… - Nature cell …, 2015 - nature.com
Primitive streak formation in the chick embryo involves large-scale highly coordinated flows
of more than 100,000 cells in the epiblast. These large-scale tissue flows and deformations …
of more than 100,000 cells in the epiblast. These large-scale tissue flows and deformations …
Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy
AN Sharpe, MS Oldach, VN Rivas, JL Kaplan… - Scientific Reports, 2023 - nature.com
Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in
humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase …
humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase …
Non‐muscle myosins in tumor progression, cancer cell invasion, and metastasis
JL Ouderkirk, M Krendel - Cytoskeleton, 2014 - Wiley Online Library
The actin cytoskeleton, which regulates cell polarity, adhesion, and migration, can influence
cancer progression, including initial acquisition of malignant properties by normal cells …
cancer progression, including initial acquisition of malignant properties by normal cells …
[HTML][HTML] Specific myosins control actin organization, cell morphology, and migration in prostate cancer cells
KA Makowska, RE Hughes, KJ White, CM Wells… - Cell reports, 2015 - cell.com
We investigated the myosin expression profile in prostate cancer cell lines and found that
Myo1b, Myo9b, Myo10, and Myo18a were expressed at higher levels in cells with high …
Myo1b, Myo9b, Myo10, and Myo18a were expressed at higher levels in cells with high …
An apical MRCK-driven morphogenetic pathway controls epithelial polarity
Polarized epithelia develop distinct cell surface domains, with the apical membrane
acquiring characteristic morphological features such as microvilli. Cell polarization is driven …
acquiring characteristic morphological features such as microvilli. Cell polarization is driven …
The future of heart failure with preserved ejection fraction: Deep phenoty** for targeted therapeutics
Heart failure (HF) with preserved ejection fraction (HFpEF) is a multi-organ, systemic
syndrome that involves multiple cardiac and extracardiac pathophysiologic abnormalities …
syndrome that involves multiple cardiac and extracardiac pathophysiologic abnormalities …