Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to a complex family of RNA-
binding proteins that are essential to control alternative splicing, mRNA trafficking, synaptic …

Tau protein is associated with many neurodegenerative disorders known as tauopathies.
Aggregates of tau are thought of as a main contributor to neurodegeneration in these …

During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study human neural development and disease. Especially in the field of Alzheimer's …

Monoclonal antibodies have emerged as a leading therapeutic agent for the treatment of
disease, including Alzheimer's disease. In the last year, two anti-amyloid monoclonal …

The self-aggregation of amyloid-β (Aβ) and tau proteins are closely implicated in Alzheimer's
disease (AD). Recent evidence indicates that Aβ and tau proteins can cross-interact to form …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases among
the older population. Its main pathological features include the abnormal deposition of …

Before the controversial approval of humanized monoclonal antibody lecanemab, which
binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for …

Purpose Pathophysiological hallmarks of Alzheimer's disease (AD) include extracellular
amyloid plaques and intracellular neurofibrillary tangles. Recent studies also demonstrated …

Large-scale plasma proteomics studies have been transformed due to the multiplexing and
automation of sample preparation workflows. However, these workflows can suffer from …

The amyloid concept of Alzheimer's disease (AD) assumes the β-amyloid peptide (Aβ) as
the main pathogenic factor, which injures neural and other brain cells, causing their …