Crucial prerequisites for the development of safe preclinical protocols in biomedical
research are suitable animal models that would allow for human‐related validation of …

Building on the successful structure of the first edition, the second edition of Reproductive
Technologies in Farm Animals has been totally updated and revised to provide an up to date …

Transgenic pigs are promising donor organisms for xenotransplantation as they share many
anatomical and physiological characteristics with humans. The most profound barrier to pig …

Decay-accelerating factor ([DAF] CD55) is a glycosylphosphatidylinositol-anchored
membrane inhibitor of complement with broad clinical relevance. Here, we establish an …

Background The similarities between swine and humans in physiological and genomic
patterns, and the great correlation in size and anatomy, make pigs extremely useful in …

Recent developments in studies of sperm‐mediated gene transfer (SMGT) now provide solid
ground for the notion that sperm cells can act as vectors for exogenous genetic sequences …

Transgenic animal bioreactors represent a powerful tool to address the growing need for
therapeutic recombinant proteins. The ability of transgenic animals to produce complex …

Transgenic animals are an important source of protein and nutrition for most humans and
will play key roles in satisfying the increasing demand for food in an ever-increasing world …

Transgenic animals have become a key tool in functional genomics to generate models for
human diseases and validate new drugs. Transgenesis includes the addition of foreign …

Microinjection of foreign DNA into pronuclei of a fertilized oocyte has predominantly been
used for the generation of transgenic livestock. This technology works reliably, but is …