Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged
heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular …

Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for
significant mortality and morbidity worldwide. The genus comprises more than seventy …

ZIKA virus (ZIKV) is an emerging pathogen responsible for neurological disorders and
congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains …

The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with
rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we …

Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live
attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR …

Yellow fever (YF) was one of the most dangerous infectious diseases of the 18th and 19th
centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is …

The flaviviruses are small single-stranded RNA viruses that are typically transmitted by
mosquito or tick vectors. These “arboviruses” are found around the world and account for a …

The disease yellow fever (YF) is prevented by a live-attenuated vaccine, termed 17D, which
has been in use since the 1930s. One dose of the vaccine is thought to give lifelong (35+ …

Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to
enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an …

The clinical syndrome referred to as viral hemorrhagic fever (VHF) can be caused by several
different families of RNA viruses, including select members of the arenaviruses …