Scientists have been trying to identify every gene in the human genome since the initial draft
was published in 2001. In the years since, much progress has been made in identifying …

Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Abstract The UCSC Genome Browser (https://genome. ucsc. edu) is a widely utilized web-
based tool for visualization and analysis of genomic data, encompassing over 4000 …

Measures of selective constraint on genes have been used for many applications, including
clinical interpretation of rare coding variants, disease gene discovery and studies of genome …

Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …

Since its initial release in 2001, the human reference genome has undergone continuous
improvement in quality, and the recently released telomere-to-telomere (T2T) version—T2T …

The term 'RNA-seq'refers to a collection of assays based on sequencing experiments that
involve quantifying RNA species from bulk tissue, single cells or single nuclei. The kallisto …

Long-read RNA sequencing is essential to produce accurate and exhaustive annotation of
eukaryotic genomes. Despite advancements in throughput and accuracy, achieving reliable …

Abstract Ensembl (www. ensembl. org) is an open platform integrating publicly available
genomics data across the tree of life with a focus on eukaryotic species related to human …

CHESS 3 represents an improved human gene catalog based on nearly 10,000 RNA-seq
experiments across 54 body sites. It significantly improves current genome annotation by …