What turns CREB on? And off? And why does it matter?
A Steven, M Friedrich, P Jank, N Heimer… - Cellular and Molecular …, 2020 - Springer
Altered expression and function of the transcription factor cyclic AMP response-binding
protein (CREB) has been identified to play an important role in cancer and is associated with …
protein (CREB) has been identified to play an important role in cancer and is associated with …
[HTML][HTML] SIRT6 promotes hepatic beta-oxidation via activation of PPARα
S Naiman, FK Huynh, R Gil, Y Glick, Y Shahar… - Cell reports, 2019 - cell.com
The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression
analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling …
analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling …
Targeting DNA binding proteins for cancer therapy
Y Shiroma, R Takahashi, Y Yamamoto… - Cancer …, 2020 - Wiley Online Library
Dysregulation or mutation of DNA binding proteins such as transcription factors (TFs) is
associated with the onset and progression of various types of disease, including cancer …
associated with the onset and progression of various types of disease, including cancer …
Exclusive temporal stimulation of IL-10 expression in LPS-stimulated mouse macrophages by cAMP inducers and type I interferons
Expression of the key anti-inflammatory cytokine IL-10 in lipopolysaccharide (LPS)-
stimulated macrophages is mediated by a delayed autocrine/paracrine loop of type I …
stimulated macrophages is mediated by a delayed autocrine/paracrine loop of type I …
Pseudouridines on Trypanosoma brucei spliceosomal small nuclear RNAs and their implication for RNA and protein interactions
The parasite Trypanosoma brucei, the causative agent of slee** sickness, cycles between
an insect and a mammalian host. Here, we investigated the presence of pseudouridines …
an insect and a mammalian host. Here, we investigated the presence of pseudouridines …
Pseudouridines on Trypanosoma brucei mRNAs are developmentally regulated: Implications to mRNA stability and protein binding
The parasite Trypanosoma brucei cycles between an insect and a mammalian host and is
the causative agent of slee** sickness. Here, we performed high‐throughput map** of …
the causative agent of slee** sickness. Here, we performed high‐throughput map** of …
[HTML][HTML] Microfluidics for genome-wide studies involving next generation sequencing
Next-generation sequencing (NGS) has revolutionized how molecular biology studies are
conducted. Its decreasing cost and increasing throughput permit profiling of genomic …
conducted. Its decreasing cost and increasing throughput permit profiling of genomic …
Multi-faceted regulation of CREB family transcription factors
MAR Chowdhury, MM Haq, JH Lee… - Frontiers in Molecular …, 2024 - frontiersin.org
cAMP response element-binding protein (CREB) is a ubiquitously expressed nuclear
transcription factor, which can be constitutively activated regardless of external stimuli or be …
transcription factor, which can be constitutively activated regardless of external stimuli or be …
Go with the flow—Microfluidics approaches for amyloid research
The rapid development of cost‐efficient microfluidic devices has received tremendous
attention from scientists of diverse fields. The growing potential of utilizing microfluidic …
attention from scientists of diverse fields. The growing potential of utilizing microfluidic …
Rapid Biosensing Method for Detecting Protein–DNA Interactions
Identifying and investigating protein–DNA interactions, which play significant roles in many
biological processes, is essential for basic and clinical research. Current techniques for …
biological processes, is essential for basic and clinical research. Current techniques for …