Long covid—mechanisms, risk factors, and management

H Crook, S Raza, J Nowell, M Young, P Edison - bmj, 2021 - bmj.com
Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on
the lives and health of people around the globe. As of 4 July 2021, more than 183 million …

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

S Beyerstedt, EB Casaro, ÉB Rangel - European journal of clinical …, 2021 - Springer
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-
converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell …

Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution

B Li, W Zhang, C Guo, H Xu, L Li, M Fang, Y Hu… - Nature …, 2022 - nature.com
Spatial transcriptomics approaches have substantially advanced our capacity to detect the
spatial distribution of RNA transcripts in tissues, yet it remains challenging to characterize …

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - Nature, 2022 - nature.com
There is strong evidence of brain-related abnormalities in COVID-19,,,,,,,,,,,–. However, it
remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder …

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

M Khan, SJ Yoo, M Clijsters, W Backaert, A Vanstapel… - Cell, 2021 - cell.com
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure …

SARS-CoV-2 infection of the oral cavity and saliva

N Huang, P Pérez, T Kato, Y Mikami, K Okuda… - Nature medicine, 2021 - nature.com
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …

COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

GD De Melo, F Lazarini, S Levallois… - Science translational …, 2021 - science.org
Whereas recent investigations have revealed viral, inflammatory, and vascular factors
involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung …

The SARS-CoV-2 as an instrumental trigger of autoimmunity

A Dotan, S Muller, D Kanduc, P David, G Halpert… - Autoimmunity …, 2021 - Elsevier
Autoimmunity may be generated by a variety of factors by creating a hyper-stimulated state
of the immune system. It had been established long ago that viruses are a substantial …

[HTML][HTML] Periodontal disease: the good, the bad, and the unknown

LM Sedghi, M Bacino, YL Kapila - Frontiers in cellular and infection …, 2021 - frontiersin.org
Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium

JB Finlay, DH Brann, R Abi Hachem, DW Jang… - Science translational …, 2022 - science.org
SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss.
Although these alterations are often transient, many patients with COVID-19 exhibit olfactory …