Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
The severe acute respiratory syndrome coronavirus 2 associated coronavirus disease 2019
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …

FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug resistance …, 2020 - Elsevier
In December 2019, a novel SARS-CoV-2 coronavirus emerged, causing an outbreak of life-
threatening pneumonia in the Hubei province, China, and has now spread worldwide …

The role of lysosomes in metabolic and autoimmune diseases

F Gros, S Muller - Nature Reviews Nephrology, 2023 - nature.com
Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

[HTML][HTML] Adjunct immunotherapies for the management of severely ill COVID-19 patients

SR Bonam, SV Kaveri, A Sakuntabhai, L Gilardin… - Cell Reports …, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). It has infected millions, with more than 275,000 fatal cases as …

Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19

ZN Lei, ZX Wu, S Dong, DH Yang, L Zhang, Z Ke… - Pharmacology & …, 2020 - Elsevier
Abstract Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for
the treatment and prevention of malaria, and the treatment of autoimmune diseases for …

[HTML][HTML] Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches

B Jahangiri, AK Saei, PO Obi, N Asghari… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Exosomal release pathway and autophagy together maintain homeostasis and survival of
cells under stressful conditions. Autophagy is a catabolic process through which cell entities …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

The interplay between emerging human coronavirus infections and autophagy

Z Zhao, K Lu, B Mao, S Liu, M Trilling… - Emerging microbes & …, 2021 - Taylor & Francis
Following outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV) and the
Middle East respiratory syndrome coronavirus (MERS-CoV) in 2002 and 2012, respectively …

Chloroquine and hydroxychloroquine for the prevention and treatment of COVID-19: A fiction, hope or hype? An updated review

SAM Saghir, NA AlGabri, MM Alagawany… - … and clinical risk …, 2021 - Taylor & Francis
In December 2019, the novel coronavirus disease pandemic (COVID-19) that began in
China had infected so far more than 109,217,366 million individuals worldwide and …

Vitamin D in autophagy signaling for health and diseases: Insights on potential mechanisms and future perspectives

SK Bhutia - The Journal of Nutritional Biochemistry, 2022 - Elsevier
Vitamin D regulates the pleiotropic effect to maintain cellular homeostasis and
epidemiological evidence establishes an association between vitamin D deficiency and …