Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies

R Kaur, M Kaur, J Singh - Cardiovascular diabetology, 2018 - Springer
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an
alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes …

Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases

S Piera-Velazquez, SA Jimenez - Physiological reviews, 2019 - journals.physiology.org
Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery

M Hu, X Li, Z You, R Cai, C Chen - Advanced Materials, 2024 - Wiley Online Library
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

The safety of ingested caffeine: a comprehensive review

JL Temple, C Bernard, SE Lipshultz… - Frontiers in …, 2017 - frontiersin.org
Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of
caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to …

Human nitric oxide synthase—Its functions, polymorphisms, and inhibitors in the context of inflammation, diabetes and cardiovascular diseases

M Król, M Kepinska - International Journal of Molecular Sciences, 2020 - mdpi.com
In various diseases, there is an increased production of the free radicals needed to carry out
certain physiological processes but their excessive amounts can cause oxidative stress and …

Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration

S Stegen, N Van Gastel, G Carmeliet - Bone, 2015 - Elsevier
Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

Coaxial cell printing of freestanding, perfusable, and functional in vitro vascular models for recapitulation of native vascular endothelium pathophysiology

G Gao, JY Park, BS Kim, J Jang… - Advanced healthcare …, 2018 - Wiley Online Library
Abstract 3D printing technology is used to produce channels within hydrogels followed by
endothelial cells (ECs)‐seeding to establish in vitro vascular models. However, as built‐in …

[HTML][HTML] Lipopolysaccharide signaling in endothelial cells

SM Dauphinee, A Karsan - Laboratory investigation, 2006 - Elsevier
Sepsis is the systemic immune response to severe bacterial infection. The innate immune
recognition of bacterial and viral products is mediated by a family of transmembrane …

Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease

P Grammas - Journal of neuroinflammation, 2011 - Springer
Alzheimer's disease (AD) is an age-related disorder characterized by progressive cognitive
decline and dementia. Alzheimer's disease is an increasingly prevalent disease with 5.3 …

An introductory review of cell mechanobiology

JHC Wang, BP Thampatty - Biomechanics and modeling in …, 2006 - Springer
Mechanical loads induce changes in the structure, composition, and function of living
tissues. Cells in tissues are responsible for these changes, which cause physiological or …