Etiology and pathogenesis of late-onset Alzheimer's disease

BJ Balin, AP Hudson - Current allergy and asthma reports, 2014 - Springer
Alzheimer's disease (AD) is a neurodegenerative condition that occurs in two forms, an early-
onset form that is genetically determined and a far more common late-onset form that is not …

Membrane damage induced by amyloid beta and a potential link with neuroinflammation

E J. Fernandez-Perez, C Peters… - Current pharmaceutical …, 2016 - benthamdirect.com
It is well accepted that cortical and hippocampal synaptic densities are reduced in
Alzheimer's disease (AD). These alterations in neuronal networking occur at the very onset …

The citrus flavonoid, nobiletin inhibits neuronal inflammation by preventing the activation of NF-κB

T Murata, S Ishiwa, X Lin, Y Nakazawa, K Tago… - Neurochemistry …, 2023 - Elsevier
Abstract Nobiletin (5, 6, 7, 8, 3′, 4′-hexamethoxyflavone) is one of the flavonoids found in
shikuwasa, a popular citrus fruit in Okinawa, Japan. It exerts various pharmacological …

ZnO Nanoflower petals mediated amyloid degradation-An in vitro electrokinetic potential approach

A Girigoswami, M Ramalakshmi, N Akhtar… - Materials Science and …, 2019 - Elsevier
An electrokinetic potential (ζ-potential) based approach was introduced to address the
amyloid degradation on ZnO-nanoflower platform. The hallmark of neurodegenerative …

[HTML][HTML] Suppression of neuroinflammation by coffee component pyrocatechol via inhibition of NF-κB in microglia

T Murata, K Tago, K Miyata, Y Moriwaki… - International journal of …, 2023 - mdpi.com
According to numerous studies, it has been epidemiologically suggested that habitual coffee
intake seems to prevent the onset of neurodegenerative diseases. In this study, we …

Pharmacological approaches for Alzheimer's disease: neurotransmitter as drug targets

A Prakash, J Kalra, V Mani, K Ramasamy… - Expert review of …, 2015 - Taylor & Francis
Alzheimer's disease (AD) is the most common CNS disorder occurring worldwide. There is
neither proven effective prevention for AD nor a cure for patients with this disorder. Hence …

Exploring the role of P2X receptors in Alzheimer's disease

PA Godoy, O Ramírez-Molina… - Frontiers in …, 2019 - frontiersin.org
Several studies have pointed to soluble oligomers of beta amyloid peptide (SOAβ) as the
principal neurotoxic agents responsible for the generation of synaptotoxic events that can …

Neuroprotective properties of Eudesmin on a cellular model of amyloid-β peptide toxicity

C Castillo, G Bravo-Arrepol, A Wendt… - Journal of …, 2023 - content.iospress.com
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
progressive cognitive impairment and memory loss. One of the hallmarks in AD is amyloid-ß …

Ibuprofen targets neuronal pentraxins expresion and improves cognitive function in mouse model of AlCl3-induced neurotoxicity

A Jamil, A Mahboob, T Ahmed - Experimental and …, 2016 - spandidos-publications.com
Aluminum is known to exert neurotoxic effects associated with various neurodegenerative
disorders, including Alzheimer's disease (AD). Ibuprofen is a well-known non-steroidal anti …