Human oocyte maturation is considered as the reinitiation and completion of the first meiotic
division from the germinal vesicle stage (prophase I) to metaphase II, and the accompanying …

The idea that Cdc2 and cyclins play a key role in the control of the G2/M transition of the cell
cycle came largely from genetic analysis of fission yeast and physiological studies of clam …

The reliable and efficient production of microalgae in large-scale commercial culture,
whether in open ponds or in closed photobioreactors, requires a good understanding of the …

A minimal model for the mitotic oscillator is presented. The model, built on recent
experimental advances, is based on the cascade of post-translational modification that …

The cell-cycle oscillator includes an essential negative-feedback loop: Cdc2 activates the
anaphase-promoting complex (APC), which leads to cyclin destruction and Cdc2 …

The cdc2 kinase is a key regulator of the eukaryotic cell cycle. The activity of its catalytic
subunit, p34cdc2, is controlled by cell cycle dependent interactions with other proteins as …

Like early Xenopus embryos, extracts made from Xenopus eggs lack the cell cycle
checkpoint that keeps anaphase from occurring before spindle assembly is complete. At …

It is clear that de novo protein synthesis has an important function in synaptic transmission
and plasticity. A substantial amount of work has shown that mRNA translation in the …

Cyclins play a key role in the induction of mitosis. In this paper we report the isolation of a
cyclin A cDNA clone from Xenopus eggs. Its cognate mRNA encodes a protein that shows …

In vertebrates, entry into mitosis is accompanied by dephosphorylation of p34cdc2 kinase on
threonine 14 (Thr14) and tyrosine 15 (Tyr15). To examine the role of these residues in …