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[HTML][HTML] Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: a review
Clinical trials are time consuming, expensive, and often burdensome on patients. Clinical
trials can fail for many reasons. This survey reviews many of these reasons and offers …
trials can fail for many reasons. This survey reviews many of these reasons and offers …
Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis
Objective To investigate the impact of patient and public involvement (PPI) on rates of
enrolment and retention in clinical trials and explore how this varies with the context and …
enrolment and retention in clinical trials and explore how this varies with the context and …
[HTML][HTML] Robot assisted training for the upper limb after stroke (RATULS): a multicentre randomised controlled trial
Background Loss of arm function is a common problem after stroke. Robot-assisted training
might improve arm function and activities of daily living. We compared the clinical …
might improve arm function and activities of daily living. We compared the clinical …
Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!
Background The current CONSORT guidelines for reporting pilot trials do not recommend
hypothesis testing of clinical outcomes on the basis that a pilot trial is under-powered to …
hypothesis testing of clinical outcomes on the basis that a pilot trial is under-powered to …
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …
trials. However, the completeness of trial protocols is often inadequate. To help improve the …
Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology …
Background Substantial amounts of public funds are invested in health research worldwide.
Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower …
Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower …
The effect of fall prevention exercise programmes on fall induced injuries in community dwelling older adults: systematic review and meta-analysis of randomised …
Objective To determine whether, and to what extent, fall prevention exercise interventions for
older community dwelling people are effective in preventing different types of fall related …
older community dwelling people are effective in preventing different types of fall related …
Why do patients take part in research? An overview of systematic reviews of psychosocial barriers and facilitators
Background Understanding why people take part in health research is critical to improve
research efficiency and generalisability. The aim of this overview of systematic reviews was …
research efficiency and generalisability. The aim of this overview of systematic reviews was …
[HTML][HTML] Clinical trials recruitment planning: a proposed framework from the clinical trials transformation initiative
GD Huang, J Bull, KJ McKee, E Mahon, B Harper… - Contemporary clinical …, 2018 - Elsevier
Patient recruitment is widely recognized as a key determinant of success for clinical trials.
Yet a substantial number of trials fail to reach recruitment goals—a situation that has …
Yet a substantial number of trials fail to reach recruitment goals—a situation that has …
Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study
Background External pilot or feasibility studies can be used to estimate key unknown
parameters to inform the design of the definitive randomised controlled trial (RCT). However …
parameters to inform the design of the definitive randomised controlled trial (RCT). However …