Tumor neoantigens: building a framework for personalized cancer immunotherapy
It is now well established that the immune system can recognize develo** cancers and
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
Early farmers from across Europe directly descended from Neolithic Aegeans
Z Hofmanová, S Kreutzer… - Proceedings of the …, 2016 - National Acad Sciences
Farming and sedentism first appeared in southwestern Asia during the early Holocene and
later spread to neighboring regions, including Europe, along multiple dispersal routes …
later spread to neighboring regions, including Europe, along multiple dispersal routes …
High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
Abstract Knowledge of “actionable” somatic genomic alterations present in each tumor (eg,
point mutations, small insertions/deletions, and copy-number alterations that direct …
point mutations, small insertions/deletions, and copy-number alterations that direct …
Target capture and massively parallel sequencing of ultraconserved elements for comparative studies at shallow evolutionary time scales
Comparative genetic studies of non-model organisms are transforming rapidly due to major
advances in sequencing technology. A limiting factor in these studies has been the …
advances in sequencing technology. A limiting factor in these studies has been the …
Target enrichment of ultraconserved elements from arthropods provides a genomic perspective on relationships among H ymenoptera
Gaining a genomic perspective on phylogeny requires the collection of data from many
putatively independent loci across the genome. Among insects, an increasingly common …
putatively independent loci across the genome. Among insects, an increasingly common …
[HTML][HTML] Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
Small cell lung carcinoma (SCLC) is a highly lethal, smoking-associated cancer with few
known targetable genetic alterations. Using genome sequencing, we characterized the …
known targetable genetic alterations. Using genome sequencing, we characterized the …
Explosive diversification of marine fishes at the Cretaceous–Palaeogene boundary
Abstract The Cretaceous–Palaeogene (K–Pg) mass extinction is linked to the rapid
emergence of ecologically divergent higher taxa (for example, families and orders) across …
emergence of ecologically divergent higher taxa (for example, families and orders) across …
Optimization of multigene analysis of tumor samples
D Lipson, GA Otto, AN Parker, PJ Stephens… - US Patent …, 2016 - Google Patents
Methods disclosed herein provide integration of one or more optimized elements including
bait-based selection, alignment, and mutation calling, as applied, eg, to optimized sets of …
bait-based selection, alignment, and mutation calling, as applied, eg, to optimized sets of …
Not all sequence tags are created equal: designing and validating sequence identification tags robust to indels
BC Faircloth, TC Glenn - 2012 - journals.plos.org
Ligating adapters with unique synthetic oligonucleotide sequences (sequence tags) onto
individual DNA samples before massively parallel sequencing is a popular and efficient way …
individual DNA samples before massively parallel sequencing is a popular and efficient way …
Sequence capture and phylogenetic utility of genomic ultraconserved elements obtained from pinned insect specimens
Obtaining sequence data from historical museum specimens has been a growing research
interest, invigorated by next-generation sequencing methods that allow inputs of highly …
interest, invigorated by next-generation sequencing methods that allow inputs of highly …