Glycogen synthase kinases: Moonlighting proteins with theranostic potential in cancer

S Nagini, J Sophia, R Mishra - Seminars in cancer biology, 2019 - Elsevier
Abstract Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase is an archetypal
multifunctional moonlighting protein involved in diverse cellular processes including …

The role of ubiquitination and deubiquitination in the regulation of cell junctions

J Cai, MK Culley, Y Zhao, J Zhao - Protein & cell, 2018 - Springer
Maintenance of cell junctions plays a crucial role in the regulation of cellular functions
including cell proliferation, permeability, and cell death. Disruption of cell junctions is …

[HTML][HTML] Potential anti-cancer properties of malvidin and its glycosides: Evidence from in vitro and in vivo studies

R Sood, HK Choi, HJ Lee - Journal of Functional Foods, 2024 - Elsevier
Malvidin and its glycosides have been studied for their anti-carcinogenic potential in various
forms of cancer, however the in-depth review for malvidin and its glycosides in in vitro and in …

New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis

S Lai, P Wang, J Gong, S Zhang - PeerJ, 2023 - peerj.com
Abstract Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed
in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

3, 3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through …

P Zhu, H Yu, K Zhou, Y Bai, R Qi, S Zhang - Journal of Experimental & …, 2020 - Springer
Background Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive
tumors in the world. Aryl hydrocarbon receptor (AHR) has been reported to promote tumor …

Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TSC2/mTORC1/autophagy pathway

Y Miao, Q Lv, S Qiao, L Yang, Y Tao, W Yan… - Toxicology and Applied …, 2019 - Elsevier
The injury of intestinal epithelial barrier is considered as the key pathophysiological process
in response to gastrointestinal infection and inflammation, and plays an important role in the …

Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis

S Nothdurft, C Thumser-Henner, F Breitenbücher… - Oncogenesis, 2020 - nature.com
Lung cancer mortality largely results from metastasis. Despite curative surgery many
patients with early-stage non-small cell lung cancer ultimately succumb to metastatic …

p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism

B Pappas, Y Yang, Y Wang, K Kim, HJ Chung… - Biochemical …, 2018 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-activated signaling molecule which is
involved in diverse biological functions ranging from cancer metastasis to immune …

[HTML][HTML] Regulation of soluble E-cadherin signaling in non-small-cell lung cancer cells by nicotine, BDNF, and β-adrenergic receptor ligands

R Ray, S Goel, H Al Khashali, B Darweesh, B Haddad… - Biomedicines, 2023 - mdpi.com
The ectodomain of the transmembrane protein E-cadherin can be cleaved and released in a
soluble form referred to as soluble E-cadherin, or sE-cad, accounting for decreased E …