The intestine as an endocrine organ and the role of gut hormones in metabolic regulation
R Bany Bakar, F Reimann, FM Gribble - … reviews Gastroenterology & …, 2023 - nature.com
Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …
The intestinal epithelium–fluid fate and rigid structure from crypt bottom to villus tip
V Bonis, C Rossell, H Gehart - Frontiers in cell and developmental …, 2021 - frontiersin.org
The single-layered, simple epithelium of the gastro-intestinal tract controls nutrient uptake,
coordinates our metabolism and shields us from pathogens. Despite its seemingly simple …
coordinates our metabolism and shields us from pathogens. Despite its seemingly simple …
Cells of the human intestinal tract mapped across space and time
The cellular landscape of the human intestinal tract is dynamic throughout life, develo** in
utero and changing in response to functional requirements and environmental exposures …
utero and changing in response to functional requirements and environmental exposures …
BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states
Intestinal epithelial cells derive from stem cells at the crypt base and travel along the crypt-
villus axis to die at the villus tip. The two dominant villus epithelial cell types, absorptive …
villus axis to die at the villus tip. The two dominant villus epithelial cell types, absorptive …
Description and functional validation of human enteroendocrine cell sensors
Enteroendocrine cells (EECs) are gut epithelial cells that respond to intestinal contents by
secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric …
secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric …
[HTML][HTML] A focus on enterochromaffin cells among the enteroendocrine cells: localization, morphology, and role
R Rezzani, C Franco, L Franceschetti, M Gianò… - International Journal of …, 2022 - mdpi.com
The intestinal epithelium plays a key role in managing the relationship with the environment,
the internal and external inputs, and their changes. One percent of the gut epithelium is …
the internal and external inputs, and their changes. One percent of the gut epithelium is …
Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals
As a highly regenerative organ, the intestine is a promising source for cellular
reprogramming for replacing lost pancreatic β cells in diabetes. Gut enterochromaffin cells …
reprogramming for replacing lost pancreatic β cells in diabetes. Gut enterochromaffin cells …
Intestinal enteroendocrine cells: present and future druggable targets
R Atanga, V Singh, JG In - International journal of molecular sciences, 2023 - mdpi.com
Enteroendocrine cells are specialized secretory lineage cells in the small and large
intestines that secrete hormones and peptides in response to luminal contents. The various …
intestines that secrete hormones and peptides in response to luminal contents. The various …
What is an L-cell and how do we study the secretory mechanisms of the L-cell?
Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-
diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and …
diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and …
[HTML][HTML] Less is more: rare pulmonary neuroendocrine cells function as critical sensors in lung
Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely
harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond …
harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond …