Towards a synthetic cell cycle

L Olivi, M Berger, RNP Creyghton… - Nature …, 2021 - nature.com
Recent developments in synthetic biology may bring the bottom-up generation of a synthetic
cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which …

Fundamental principles in bacterial physiology—history, recent progress, and the future with focus on cell size control: a review

S Jun, F Si, R Pugatch, M Scott - Reports on Progress in Physics, 2018 - iopscience.iop.org
Bacterial physiology is a branch of biology that aims to understand overarching principles of
cellular reproduction. Many important issues in bacterial physiology are inherently …

Mechanistic origin of cell-size control and homeostasis in bacteria

F Si, G Le Treut, JT Sauls, S Vadia, PA Levin, S Jun - Current Biology, 2019 - cell.com
Evolutionarily divergent bacteria share a common phenomenological strategy for cell-size
homeostasis under steady-state conditions. In the presence of inherent physiological …

Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria

R Balakrishnan, M Mori, I Segota, Z Zhang… - Science, 2022 - science.org
Protein concentrations are set by a complex interplay between gene-specific regulatory
processes and systemic factors, including cell volume and shared gene expression …

Cellular perception of growth rate and the mechanistic origin of bacterial growth law

C Wu, R Balakrishnan, N Braniff… - Proceedings of the …, 2022 - National Acad Sciences
Many cellular activities in bacteria are organized according to their growth rate. The notion
that ppGpp measures the cell's growth rate is well accepted in the field of bacterial …

How to build a bacterial cell: MreB as the foreman of E. coli construction

H Shi, BP Bratton, Z Gitai, KC Huang - Cell, 2018 - cell.com
Cell shape matters across the kingdoms of life, and cells have the remarkable capacity to
define and maintain specific shapes and sizes. But how are the shapes of micron-sized cells …

Sizing up the bacterial cell cycle

L Willis, KC Huang - Nature Reviews Microbiology, 2017 - nature.com
It is remarkable how robustly a bacterial species can maintain its preferred size. This
capacity is intimately related to control of the cell cycle: cell size and growth rate determine …

[HTML][HTML] Apparent simplicity and emergent robustness in the control of the Escherichia coli cell cycle

SK Govers, M Campos, B Tyagi, G Laloux… - Cell Systems, 2024 - cell.com
To examine how bacteria achieve robust cell proliferation across diverse conditions, we
developed a method that quantifies 77 cell morphological, cell cycle, and growth …

Surface area to volume ratio: a natural variable for bacterial morphogenesis

LK Harris, JA Theriot - Trends in microbiology, 2018 - cell.com
An immediately observable feature of bacteria is that cell size and shape are remarkably
constant and characteristic for a given species in a particular condition, but vary …

Antibiotic resistance via bacterial cell shape-shifting

N Ojkic, D Serbanescu, S Banerjee - Mbio, 2022 - Am Soc Microbiol
Bacteria have evolved to develop multiple strategies for antibiotic resistance by effectively
reducing intracellular antibiotic concentrations or antibiotic binding affinities, but the role of …