The DNA-binding transcription factor PAX6 was cloned 25 years ago by multiple teams
pursuing identification of human and mouse eye disease causing genes, cloning vertebrate …

Among the mechanisms that steer cells to their correct fate during development, master
regulatory networks are unique in their sufficiency to trigger a developmental program …

The Drosophila eye is a powerful model system to study the dynamics of cell differentiation,
cell state transitions, cell maturation, and pattern formation. However, a high-resolution …

SIX homeoproteins were first described in Drosophila, where they participate in the Pax-Six-
Eya-Dach (PSED) network with eyeless, eyes absent and dachsund to drive synergistically …

The purpose of the present study was to analyze the crucial role of microRNAs
(miRNAs/miRs) involved in the proliferation and migration of colorectal cancer (CRC) and to …

The adult Drosophila eye is a powerful model system for phototransduction and
neurodegeneration research. However, single cell resolution transcriptomic data are lacking …

Background Renal cell carcinoma (RCC) is a complex with diverse biological characteristics
and distinct molecular signature. New target therapies to molecules that drive RCC initiation …

Columnar structure is a basic unit of the brain, but the mechanism underlying its
development remains largely unknown. The medulla, the largest ganglion of the Drosophila …

Pioneering molecular work on chelicerate visual system development in the horseshoe crab
Limulus polyphemus surprised with the possibility that this process may not depend on the …

Whole-genome and transcriptome sequencing of non-small cell lung cancer (NSCLC)
identified that DACH1, is a human homolog of drosophila gene dac, is involved in NSCLC …