Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …

Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …

Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …

Treatment of 3-cyanoacetyl indole 1 with the diazonium salts of 3-phenyl-5-aminopyrazole
and 2-aminobenzimidazole afforded the corresponding hydrazones 4 and 5. 3-Cyanoacetyl …

Treatment of 2-bromoacetylbenzofuran with 1H-benzotriazole afforded 1-(benzofuran-2-yl)-2-
(benzotriazol-1-yl) ethanone which reacted with phenylisothiocyanate to give the …

The Neurovascular Unit (NVU) is an important multicellular structure of the central nervous
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …

Introduction: All microorganisms that cause diseases or illnesses to their host are defined as
pathogens. In this paper we will review the current state of the art for inhibiting parasite …

Introduction: An epileptic seizure is a transient occurrence of signs and/or symptoms due to
abnormal excessive or synchronous neuronal activity in the brain. The International League …

The search for antiepileptic compounds with more selective activity and lower toxicity
continues to be an area of intensive investigation in medicinal chemistry. This review …