Antibiotic resistance has caused a serious threat to public health and human safety.
Recently, the emergence of novel resistance gene tet (X4) and its variants threatens the …

Abstract β-Carotene is an important bioactive component showing great activities and
receiving great attention in recent years. The traditional methods for the accurate detection …

Riboswitches are involved in regulating the gene expression in bacteria. They are located
within the untranslated regions of bacterial messenger RNA and function as switches by …

Riboswitches are mRNA segments that regulate gene expression through conformational
changes driven by their cognate ligand binding. The ykkC motif forms a riboswitch class that …

Guanidinium ion is a toxic cellular metabolite. The ykkC-III riboswitch, an mRNA stretch,
regulates the gene expression by undergoing a conformational change in response to the …

Riboswitches are structured ribonucleic acid (RNA) segments that act as specific sensors for
small molecules in bacterial metabolism. Due to the flexible nature of these highly charged …

Riboswitch RNAs regulate gene expression by conformational changes induced by
environmental conditions and specific ligand binding. The guanidine-II riboswitch is …

Understanding the structural dynamics of how small molecule ligand recognize its RNA
binding pocket is always a crucial determinant in pharmaceutical research. Molecular …

Aptamers are a type of single⁃ chain oligonucleotide that can combine with a specific target.
Due to their simple preparation, easy modification, stable structure and reusability, aptamers …

Die vorliegende Dissertation mit dem Titel “Structural dynamics of eukaryotic H/ACA RNPs
from Saccharomyces cerevisiae & Structural dynamics of the Guanidine-II riboswitch from …