[HTML][HTML] Recent advances in electrical neural interface engineering: minimal invasiveness, longevity, and scalability

L Luan, JT Robinson, B Aazhang, T Chi, K Yang, X Li… - Neuron, 2020 - cell.com
Electrical neural interfaces serve as direct communication pathways that connect the
nervous system with the external world. Technological advances in this domain are …

Ultraflexible neural electrodes for long-lasting intracortical recording

F He, R Lycke, M Ganji, C **e, L Luan - IScience, 2020 - cell.com
Implanted electrodes provide one of the most important neurotechniques for fundamental
and translational neurosciences by permitting time-resolved electrical detection of individual …

Ultraflexible nanoelectronic probes form reliable, glial scar–free neural integration

L Luan, X Wei, Z Zhao, JJ Siegel, O Potnis… - Science …, 2017 - science.org
Implanted brain electrodes construct the only means to electrically interface with individual
neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific …

Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording

TDY Kozai, K Catt, X Li, ZV Gugel, VT Olafsson… - Biomaterials, 2015 - Elsevier
Penetrating intracortical electrode arrays that record brain activity longitudinally are powerful
tools for basic neuroscience research and emerging clinical applications. However …

Explant analysis of Utah electrode arrays implanted in human cortex for brain-computer-interfaces

K Woeppel, C Hughes, AJ Herrera, JR Eles… - … in Bioengineering and …, 2021 - frontiersin.org
Brain-computer interfaces are being developed to restore movement for people living with
paralysis due to injury or disease. Although the therapeutic potential is great, long-term …

Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface

NJ Michelson, AL Vazquez, JR Eles… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Implantable neural electrode devices are important tools for neuroscience
research and have an increasing range of clinical applications. However, the intricacies of …

Long-term intracortical microelectrode array performance in a human: a 5 year retrospective analysis

SC Colachis, CF Dunlap, NV Annetta… - Journal of Neural …, 2021 - iopscience.iop.org
Objective. Brain-computer interfaces (BCIs) that record neural activity using intracortical
microelectrode arrays (MEAs) have shown promise for mitigating disability associated with …

Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy

JR Eles, AL Vazquez, NR Snyder, C Lagenaur… - Biomaterials, 2017 - Elsevier
Implantable neural electrode technologies for chronic neural recordings can restore
functional control to paralysis and limb loss victims through brain-machine interfaces. These …

Characterization of Parylene-C degradation mechanisms: In vitro reactive accelerated aging model compared to multiyear in vivo implantation

R Caldwell, MG Street, R Sharma, P Takmakov… - Biomaterials, 2020 - Elsevier
Implantable neural microelectrodes are integral components of neuroprosthetic
technologies and can transform treatments for many neural-mediated disorders. However …

Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights

TDY Kozai, JR Eles, AL Vazquez, XT Cui - Journal of neuroscience …, 2016 - Elsevier
Background Two-photon microscopy has enabled the visualization of dynamic tissue
changes to injury and disease in vivo. While this technique has provided powerful new …