Photodynamic and photothermal therapies: synergy opportunities for nanomedicine

M Overchuk, RA Weersink, BC Wilson, G Zheng - ACS nano, 2023 - ACS Publications
Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to
eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen …

Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

X Di, X Gao, L Peng, J Ai, X **, S Qi, H Li… - Signal transduction and …, 2023 - nature.com
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Harnessing nanomaterials for cancer sonodynamic immunotherapy

S Liang, J Yao, D Liu, L Rao, X Chen… - Advanced …, 2023 - Wiley Online Library
Immunotherapy has made remarkable strides in cancer therapy over the past decade.
However, such emerging therapy still suffers from the low response rates and immune …

Chemical strategies to engineer hydrogels for cell culture

J Lou, DJ Mooney - Nature Reviews Chemistry, 2022 - nature.com
Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

The fibrogenic niche in kidney fibrosis: components and mechanisms

L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

[HTML][HTML] Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

G Zhu, T Zhang, M Chen, K Yao, X Huang, B Zhang… - Bioactive materials, 2021 - Elsevier
Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …