Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements

RM Dorrian, CF Berryman, A Lauto… - Frontiers in Cellular …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

Regenerative therapies for spinal cord injury

N Ashammakhi, HJ Kim, A Ehsanipour… - … Engineering Part B …, 2019 - liebertpub.com
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …

Epidural spinal cord stimulation facilitates immediate restoration of dormant motor and autonomic supraspinal pathways after chronic neurologically complete spinal …

D Darrow, D Balser, TI Netoff, A Krassioukov… - Journal of …, 2019 - liebertpub.com
Abstract Epidural Spinal Cord Stimulation (eSCS) in combination with extensive
rehabilitation has been reported to restore volitional movement in a select group of subjects …

Epidural spinal cord stimulation as an intervention for motor recovery after motor complete spinal cord injury

JT Hachmann, A Yousak, JJ Wallner… - Journal of …, 2021 - journals.physiology.org
Spinal cord injury (SCI) commonly results in permanent loss of motor, sensory, and
autonomic function. Recent clinical studies have shown that epidural spinal cord stimulation …

[HTML][HTML] Epidural electrical stimulation for spinal cord injury

EH Choi, S Gattas, NJ Brown, JD Hong… - Neural Regeneration …, 2021 - journals.lww.com
A long-standing goal of spinal cord injury research is to develop effective repair strategies,
which can restore motor and sensory functions to near-normal levels. Recent advances in …

[HTML][HTML] Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation

AS Hofer, ME Schwab - Current opinion in neurology, 2019 - journals.lww.com
Promising treatment options have emerged from research in recent years using
neurostimulation to enable or enhance intense training. However, characterizing long-term …

Materials for implantable surface electrode arrays: current status and future directions

CM Tringides, DJ Mooney - Advanced Materials, 2022 - Wiley Online Library
Surface electrode arrays are mainly fabricated from rigid or elastic materials, and precisely
manipulated ductile metal films, which offer limited stretchability. However, the living tissues …

Emergence of epidural electrical stimulation to facilitate sensorimotor network functionality after spinal cord injury

JS Calvert, PJ Grahn, KD Zhao, KH Lee - Neuromodulation: Technology at …, 2019 - Elsevier
Background Traumatic spinal cord injury (SCI) disrupts signaling pathways between the
brain and spinal networks below the level of injury. In cases of severe SCI, permanent loss …

[HTML][HTML] Targeted selection of stimulation parameters for restoration of motor and autonomic function in individuals with spinal cord injury

C Angeli, E Rejc, M Boakye, A Herrity, S Mesbah… - … : Technology at the …, 2024 - Elsevier
Abstract Study Design This is a report of methods and tools for selection of task and
individual configurations targeted for voluntary movement, standing, step**, blood …

Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord

US Hofstoetter, B Freundl, H Binder, K Minassian - PLoS One, 2019 - journals.plos.org
Posterior root-muscle (PRM) reflexes are short-latency spinal reflexes evoked by epidural or
transcutaneous spinal cord stimulation (SCS) in clinical and physiological studies. PRM …