Endoplasmic reticulum stress in the heart: insights into mechanisms and drug targets
S Wang, P Binder, Q Fang, Z Wang… - British journal of …, 2018 - Wiley Online Library
The endoplasmic reticulum (ER) serves several essential cellular functions including protein
synthesis, protein folding, protein translocation, calcium homoeostasis and lipid …
synthesis, protein folding, protein translocation, calcium homoeostasis and lipid …
Unstructural biology of TRP ion channels: the role of intrinsically disordered regions in channel function and regulation
B Goretzki, C Guhl, F Tebbe, JM Harder… - Journal of Molecular …, 2021 - Elsevier
The first genuine high-resolution single particle cryo-electron microscopy structure of a
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …
Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control Excitability
Rationale: In cardiomyocytes, NaV1. 5 and Kir2. 1 channels interact dynamically as part of
membrane bound macromolecular complexes. Objective: The objective of this study was to …
membrane bound macromolecular complexes. Objective: The objective of this study was to …
Subcellular diversity of Nav1. 5 in cardiomyocytes: distinct functions, mechanisms and targets
In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α‐
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …
Late sodium current inhibitors as potential antiarrhythmic agents
Based on recent findings, an increased late sodium current (INa, late) plays an important
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …
Distinctive Properties and Powerful Neuromodulation of Nav1.6 Sodium Channels Regulates Neuronal Excitability
Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability.
These ion channels exist as large heteromultimeric structures and their activity is tightly …
These ion channels exist as large heteromultimeric structures and their activity is tightly …
Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5
C Dong, Y Wang, A Ma, T Wang - Frontiers in physiology, 2020 - frontiersin.org
Cardiac voltage-gated sodium channel NaV1. 5, encoded by SCN5A, is crucial for the
upstroke of action potential and excitation of cardiomyocytes. NaV1. 5 undergoes complex …
upstroke of action potential and excitation of cardiomyocytes. NaV1. 5 undergoes complex …
Unfolded protein response in cardiovascular disease
The unfolded protein response (UPR) is a highly conserved molecular machinery, which
protects the cells against a diverse variety of stimuli. Activation of this element has been …
protects the cells against a diverse variety of stimuli. Activation of this element has been …
[HTML][HTML] Brugada syndrome trafficking–defective Nav1. 5 channels can trap cardiac Kir2. 1/2.2 channels
Abstract Cardiac Nav1. 5 and Kir2. 1–2.3 channels generate Na (I Na) and inward rectifier K
(I K1) currents, respectively. The functional I Na and I K1 interplay is reinforced by the …
(I K1) currents, respectively. The functional I Na and I K1 interplay is reinforced by the …
Genomic and non-genomic regulatory mechanisms of the cardiac sodium channel in cardiac arrhythmias
H Daimi, E Lozano-Velasco, A Aranega… - International Journal of …, 2022 - mdpi.com
Nav1. 5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene,
which is involved in the initiation and conduction of action potentials throughout the heart …
which is involved in the initiation and conduction of action potentials throughout the heart …