Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Neuronal transmission relies on the regulated secretion of neurotransmitters, which are
packed in synaptic vesicles (SVs). Hundreds of SVs accumulate at synaptic boutons …

Compartmentalization by liquid-liquid phase separation (LLPS) has emerged as a
ubiquitous mechanism underlying the organization of biomolecules in space and time. Here …

Biomolecular condensates organize biochemistry, yet little is known about how cells control
the position and scale of these structures. In cells, condensates often appear as relatively …

Liquid-liquid phase separation of proteins occurs on both surfaces of cellular membranes
during diverse physiological processes. In vitro reconstitution could provide insight into the …

Cells compartmentalize parts of their interiors into liquid-like condensates, which can be
reconstituted in vitro. Although these condensates interact with membrane-bound …

Clathrin-mediated endocytosis is initiated by a network of weakly interacting proteins
through a poorly understood mechanism. Ede1, the yeast homolog of mammalian Eps15, is …

Protein recruitment to DNA break sites is an integral part of the DNA damage response
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …

In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …