In response to stress, the brain activates several neuropeptide-secreting systems. This
eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed …

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …

Background Hippocampal volume loss is a hallmark of clinical depression. Chronic stress
produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Understanding the physiopathology of affective disorders and their treatment relies on the
availability of experimental models that accurately mimic aspects of the disease. Here we …

Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

Cortical growth and remodeling continues from birth through youth and adolescence to
stable adult levels changing slowly into senescence. There are critical periods of cortical …

Stress responses entail neuroendocrine, autonomic, and behavioral changes to promote
effective co** with real or perceived threats to one's safety. While these responses are …

Co** with stress is fundamental for mental health, but understanding of the molecular
neurobiology of stress is still in its infancy. Adult neurogenesis is well known to be regulated …

Exposure to an enriched environment and physical activity, such as voluntary running,
increases neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are …