Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

M Fathi, S Majidi, PS Zangabad, J Barar… - Medicinal research …, 2018 - Wiley Online Library
Nanotechnology as an emerging field has established inevitable impacts on nano‐
biomedicine and treatment of formidable diseases, inflammations, and malignancies. In this …

Chitosan biopolymer, its derivatives and potential applications in nano-therapeutics: A comprehensive review

M Mukhtar, E Fényes, C Bartos, M Zeeshan… - European Polymer …, 2021 - Elsevier
Chitosan (CS) is a natural biopolymer used frequently in drug delivery because of its
biodegradability and biocompatibility. Several derivatives of CS have also been synthesized …

Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer

F Li, H Mei, Y Gao, X **e, H Nie, T Li, H Zhang, L Jia - Biomaterials, 2017 - Elsevier
Tumor hypoxia is a common feature of the tumor microenvironment and has been regarded
as one of the key factors in driving the emergence of drug resistance in solid tumors. To …

Chitosan modified by organo-functionalities as an efficient nanoplatform for anti-cancer drug delivery process

S Jaiswal, PK Dutta, S Kumar, R Chawla - Journal of Drug Delivery Science …, 2021 - Elsevier
Cancer, one of the lethal threats to human health, is most frequently treated with surgery,
chemotherapy and radiation. Specific receptors and abnormal physiochemical conditions …

[HTML][HTML] Codelivery of genistein and miRNA-29b to A549 cells using aptamer-hybrid nanoparticle bioconjugates

K Sacko, K Thangavel, SA Shoyele - Nanomaterials, 2019 - mdpi.com
This study aimed to evaluate the anti-cancer effect of a combination therapy of miRNA-29b
and genistein loaded in mucin-1 (MUC 1)-aptamer functionalized hybrid nanoparticles in …

Improved oral bioavailability and therapeutic efficacy of erlotinib through molecular complexation with phospholipid

CP Dora, V Kushwah, SS Katiyar, P Kumar… - International journal of …, 2017 - Elsevier
The current study was aimed to prepare a molecular complex of erlotinib (ERL) with
phospholipid (PC) for enhancement of solubility and thus bioavailability, therapeutic efficacy …

Prediction of co-amorphous formation using non-bonded interaction energy: Molecular dynamic simulation and experimental validation

Y Deng, W Luo, Z Zheng, G Wei, S Liu, Y Jiang… - Chemical Engineering …, 2023 - Elsevier
Co-amorphous (CA) formulation is a promising strategy to improve the solubility of poorly
water-soluble drugs, however, effective prediction of a CA system is a challenge. In this …

Aptamer-conjugated chitosan-anchored liposomal complexes for targeted delivery of erlotinib to EGFR-mutated lung cancer cells

F Li, H Mei, X **e, H Zhang, J Liu, T Lv, H Nie, Y Gao… - The AAPS journal, 2017 - Springer
Lung cancer is the leading cancer and has the highest death rate. The epidermal growth
factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib has had a promising response …

Study on the mechanism of surface modification of magnesium oxysulfate whisker

L Dang, X Nai, D Zhu, Y **g, X Liu, Y Dong, W Li - Applied surface science, 2014 - Elsevier
Hydrophobic-lipophilic magnesium oxysulfate whisker (MOSw) was prepared by surface
modification with lauric acid and the surface morphology of MOSw was examined with field …

Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential …

M Perepelyuk, C Maher… - International Journal …, 2016 - Taylor & Francis
MicroRNAs (miRNAs) are potentially attractive candidates for cancer therapy. However, their
therapeutic application is limited by lack of availability of an efficient delivery system to stably …