Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

Hypertension and erectile dysfunction: breaking down the challenges

AA de Oliveira, KP Nunes - American Journal of Hypertension, 2021 - academic.oup.com
A diagnostic of hypertension increases the risk of erectile dysfunction (ED); likewise, ED can
be an early sign of hypertension. In both cases, there is evidence that endothelial …

Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy

L Ji, Y Chen, H Wang, W Zhang… - … journal of oncology, 2019 - spandidos-publications.com
In this study, we aimed to investigate the associations between Sirt6, macrophages and
diabetic nephropathy (DN). Immunohistochemical, western blot and RT‑qPCR analyses …

Toll-like receptors (TLRs) in health and disease: an overview

V Kumar, JE Barrett - Toll-like Receptors in Health and Disease, 2022 - Springer
Toll-like receptors were discovered as proteins playing a crucial role in the dorsoventral
patterning during embryonic development in the Drosophila melanogaster (D …

The pathogenic role of the immune system in erectile dysfunction and Peyronie's disease: focusing on immunopathophysiology and potential therapeutic strategies

VA Giagulli, G Lisco, A De Tullio… - Sexual Medicine …, 2024 - academic.oup.com
Introduction Erectile dysfunction (ED) represents the major cause of male sexual
dysfunction, which is often associated with obesity, diabetes mellitus, atherosclerotic …

Cardiometabolic disorder and erectile dysfunction

D Adeyemi, D Arokoyo, M Hamed, A Dare… - Cell Biochemistry and …, 2024 - Springer
Erectile dysfunction (ED), which is defined as the inability to attain and maintain a
satisfactory penile erection to sufficiently permit sexual intercourse, is a consequence and …

Chrysin ameliorates STZ-induced diabetes in rats: possible impact of modulation of TLR4/NF-κβ pathway

A Salama, GF Asaad, A Shaheen - Research in pharmaceutical …, 2022 - journals.lww.com
Background and purpose: Growing evidence advocates that upregulation of toll-like receptor
4 (TLR4) has been suggested as a causative influence in the development and …

New insights into the role and therapeutic potential of HSP70 in diabetes

AA de Oliveira, VO Mendoza, S Rastogi… - Pharmacological …, 2022 - Elsevier
Emerging evidence indicates that HSP70 represents a key mechanism in the
pathophysiology of β-cell dysfunction, insulin resistance, and various diabetic complications …

New insights into RhoA/Rho-kinase signaling: a key regulator of vascular contraction

KP Nunes, RC Webb - Small GTPases, 2021 - Taylor & Francis
While Rho-signalling controlling vascular contraction is a canonical mechanism, with the
modern approaches used in research, we are advancing our understanding and details into …

Current status and prospects of diabetes mellitus induced erectile dysfunction: A bibliometric and visualization study

L Zhang, B Bao, J Guo, Z Qin, H Huang… - Frontiers in …, 2023 - frontiersin.org
Background The prevalence of diabetes mellitus-induced erectile dysfunction (DMED) has
recently increased, which has prompted numerous DMED studies. Here, we conduct a …