Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options

L Kuna, J Jakab, R Smolic, N Raguz-Lucic… - Journal of clinical …, 2019 - mdpi.com
Peptic ulcer is a chronic disease affecting up to 10% of the world's population. The formation
of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal …

Barrett esophagus and risk of esophageal cancer: a clinical review

SJ Spechler - Jama, 2013 - jamanetwork.com
Importance Barrett esophagus, a complication of gastroesophageal reflux disease (GERD),
predisposes patients to esophageal adenocarcinoma, a tumor that has increased in …

[HTML][HTML] Vonoprazan versus lansoprazole for healing and maintenance of healing of erosive esophagitis: a randomized trial

L Laine, K DeVault, P Katz, S Mitev, J Lowe, B Hunt… - Gastroenterology, 2023 - Elsevier
Background & Aims For decades, proton pump inhibitors (PPIs) have been the mainstay of
treatment for erosive esophagitis. The potassium-competitive acid blocker vonoprazan …

Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis

S Singh, SK Garg, PP Singh, PG Iyer, HB El-Serag - Gut, 2014 - gut.bmj.com
Background and aims Acid-suppressive medications, particularly proton pump inhibitors
(PPIs), may decrease the risk of oesophageal adenocarcinoma (OAC) in patients with …

Control of gastric acid secretion in health and disease

ML Schubert, DA Peura - Gastroenterology, 2008 - Elsevier
Recent milestones in the understanding of gastric acid secretion and treatment of acid-
peptic disorders include the (1) discovery of histamine H2-receptors and development of …

Cholecystokinin and gastrin receptors

M Dufresne, C Seva, D Fourmy - Physiological reviews, 2006 - journals.physiology.org
Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

Gastrin, cholecystokinin, signaling, and biological activities in cellular processes

Q Zeng, L Ou, W Wang, DY Guo - Frontiers in endocrinology, 2020 - frontiersin.org
The structurally-related peptides, gastrin and cholecystokinin (CCK), were originally
discovered as humoral stimulants of gastric acid secretion and pancreatic enzyme release …

Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?

Y Hayakawa, N Sethi, AR Sepulveda, AJ Bass… - Nature Reviews …, 2016 - nature.com
Over recent decades we have witnessed a shift in the anatomical distribution of gastric
cancer (GC), which increasingly originates from the proximal stomach near the junction with …

Reflux, Barrett's oesophagus and adenocarcinoma: burning questions

CP Wild, LJ Hardie - Nature Reviews Cancer, 2003 - nature.com
The incidence of oesophageal adenocarcinoma is increasing rapidly in Western
populations. Gastro-oesophageal reflux disease is a strong risk factor for both this tumour …

Proton pump inhibitors do not reduce the risk of esophageal adenocarcinoma in patients with Barrett's esophagus: a systematic review and meta-analysis

Q Hu, TT Sun, J Hong, JY Fang, H **ong, SJ Meltzer - PloS one, 2017 - journals.plos.org
Objectives Proton pump inhibitors (PPIs) have been used for treatment of Barrett's
esophagus (BE) for many years. However, the connection between PPIs and esophageal …