Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …

Germline GATA2 mutations cause cellular deficiencies with high propensity for myeloid
disease. We investigated 426 children and adolescents with primary myelodysplastic …

The study of gene regulation is dominated by a focus on the control of gene activation or
increase in the level of expression. Just as critical is the process of gene repression or …

Heterozygous familial or sporadic GATA 2 mutations cause a multifaceted disorder,
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …

Enhancers are the primary determinants of cell identity, but the regulatory components
controlling enhancer turnover during lineage commitment remain largely unknown. Here we …

The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …

The correct maintenance and differentiation of hematopoietic stem cells (HSC) in bone
marrow is vital for the maintenance and operation of the human blood system. GATA2 plays …

Molecular noise is a natural phenomenon that is inherent to all biological systems,. How
stochastic processes give rise to the robust outcomes that support tissue homeostasis …

Summary Polycomb repressive complex 2 (PRC2) plays crucial roles in transcriptional
regulation and stem cell development. However, the context-specific functions associated …