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Single-cell omics: experimental workflow, data analyses and applications
Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells
Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …
Unraveling non-genetic heterogeneity in cancer with dynamical models and computational tools
Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …
Gene-expression memory-based prediction of cell lineages from scRNA-seq datasets
Assigning single cell transcriptomes to cellular lineage trees by lineage tracing has
transformed our understanding of differentiation during development, regeneration, and …
transformed our understanding of differentiation during development, regeneration, and …
Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
Pluripotency can be induced in somatic cells by the expression of OCT4, KLF4, SOX2, and
MYC. Usually only a rare subset of cells reprogram, and the molecular characteristics of this …
MYC. Usually only a rare subset of cells reprogram, and the molecular characteristics of this …
Integration of quantitative methods and mathematical approaches for the modeling of cancer cell proliferation dynamics
Physiological processes rely on the control of cell proliferation, and the dysregulation of
these processes underlies various pathological conditions, including cancer. Mathematical …
these processes underlies various pathological conditions, including cancer. Mathematical …
Craniofacial developmental biology in the single-cell era
The evolution of a unique craniofacial complex in vertebrates made possible new ways of
breathing, eating, communicating and sensing the environment. The head and face develop …
breathing, eating, communicating and sensing the environment. The head and face develop …
Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells
Pluripotency can be induced in somatic cells by the expression of the four “Yamanaka”
factors OCT4, KLF4, SOX2, and MYC. However, even in homogeneous conditions, usually …
factors OCT4, KLF4, SOX2, and MYC. However, even in homogeneous conditions, usually …
Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer
Understanding transcriptional heterogeneity in cancer cells and its implication for treatment
response is critical to identify how resistance occurs and may be targeted. Such …
response is critical to identify how resistance occurs and may be targeted. Such …
Toward a systems-level probing of tumor clonality
Cancer has been described as a genetic disease that clonally evolves in the face of
selective pressures imposed by cell-intrinsic and extrinsic factors. Although classical models …
selective pressures imposed by cell-intrinsic and extrinsic factors. Although classical models …