Childhood asthma is a common chronic disease of the airways that results from host and
environment interactions. Most risk factor studies of asthma point to the first year of life as a …

Autophagy is an essential catabolic process that promotes the clearance of surplus or
damaged intracellular components. Loss of autophagy in age-related human pathologies …

The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and
transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) …

Human rhinoviruses (HRV) are common cold viruses associated with exacerbations of lower
airways diseases. Although viral induced epithelial damage mediates inflammation, the …

Background Glucose concentrations are increased in nasal secretions in chronic
rhinosinusitis (CRS). However, the glucose metabolism and its contribution to disease …

Air pollution has significant health effects worldwide, and airborne particles play a significant
role in these effects. Ultrafine particles (UFPs) have an aerodynamic diameter of 0.1 μm or …

Submerged cultures of primary human airway epithelial cells or human airway epithelial cell
lines have been a mainstay of airway epithelial biology research for decades due to their …

Positron emission tomography (PET) is a quantitative molecular imaging modality
increasingly used to study pulmonary disease processes and drug effects on those …

Impairment of autophagy leads to an accumulation of misfolded proteins and damaged
organelles and has been implicated in plethora of human diseases. Loss of autophagy in …

Chronic obstructive pulmonary disease (COPD) is a devastating lung disease primarily
caused by exposure to cigarette smoke (CS). During the pyrolysis and combustion of …