The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …

We propose that the diet-derived compound ergothioneine (ET) is an important nutrient in
the human body, especially for maintenance of normal brain function, and that low body ET …

Probenecid is used to treat gout and hyperuricemia as well as increase plasma levels of
antiviral drugs and antibiotics. In vivo, probenecid mainly inhibits the renal SLC22 organic …

In vitro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6,
NKT) and OAT3 (SLC22A8) among the main multi-specific “drug” transporters. They also …

Backgrounds Kidney stone also known as urolithiasis or nephrolithiasis, is one of the oldest
diseases known to medicine, however, the gene expression changes and related kidney …

High uric acid is associated with gout, hypertension, metabolic syndrome, cardiovascular
disease, and kidney disease. URAT1 (SLC22A12), originally discovered in mice as Rst, is …

Drug transporters and drug-metabolizing enzymes are primarily known for their role in the
absorption, distribution, metabolism, and excretion (ADME) of small molecule drugs, but they …

Transporters for organic cations (OCs) facilitate exchange of positively charged molecules
through the plasma membrane. Substrates for these transporters encompass …

Acetaminophen (APAP) overdose stands as the paramount contributor to drug-elicited liver
damage in clinical settings. Despite this, the intricate interplay between uric acid (UA) levels …

Objectives: The current study aimed to correlate OCT1 (organic cation transporter 1)
polymorphisms with metformin response variability in Iraqi women with PCOS (polycystic …