The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Background Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with
few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
cancers in humans, due to late diagnosis and limited treatment possibilities. Improved …

Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs)
state. Here, we report that mitochondrial D-lactate catabolism is a necessary initiating …

Abstract Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family of proteins
(CDK) and is critical for cancer development. Years of study into CDK12 have generated …

Understanding the molecular events controlling melanoma progression is of paramount
importance for the development of alternative treatment options for this devastating disease …

Objectives The promoting roles of cyclin dependent kinase 1 (CDK1) have been revealed in
various tumors, however, its effects in the progression of cancer stem cells are still …

Metastasis is the leading cause of melanoma-related mortality. Current therapies are rarely
curative for metastatic melanoma, revealing the urgent need to identify more effective …

Growing evidence indicates N6-methyladenosine (m6A) has biological function in
oncogenesis. METTL3, the catalytic component, is the most important part of …