Covering: up to August 2024 Enzymes play an essential role in synthesizing value-added
chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from …

Alzheimer's disease (AD) is a major neurodegenerative dementia, with its complex
pathophysiology challenging current treatments. Recent advancements have shifted the …

The ATP-binding cassette (ABC) and solute carrier (SLC) transporters play pivotal roles in
cellular transport mechanisms, influencing a wide range of physiological processes and …

Binding affinity (BA) prediction is important for drug discovery and protein engineering. It
seeks to understand the interaction strength between proteins and their ligands (or proteins) …

Biological phenomena are chemical reactions, which are inherently non-stop** or"
flowing" in nature. Molecular dynamics (MD) is used to analyze the dynamics and energetics …

The Natural Product Research Laboratory (NPRL) of China Medical University Hospital
(CMUH) was established in collaboration with CMUH and Professor Kuo-Hsiung Lee from …

This study compares four predicted models of histidine acid phosphatase (HAP) from
Saccharomyces cerevisiae generated using SWISS-MODEL, YASARA, AlphaFold2, and …

Many essential conserved functions depend, paradoxically, on proteins that evolve rapidly
under positive selection. How such adaptively evolving proteins promote biological …

The endoplasmic reticulum (ER) is a very important organelle in cellular activity, especially
in protein biosynthesis, folding, and quality control. In situations where there is stress in the …

The de novo protein design involves the computational generation of novel proteins that can
fold into specific 3D structures by coupling the innovative technologies of artificial …