[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …
drug discovery and development has been sky-rocketing, the number of approved drugs has …
Translation of human-induced pluripotent stem cells: from clinical trial in a dish to precision medicine
The prospect of changing the plasticity of terminally differentiated cells toward pluripotency
has completely altered the outlook for biomedical research. Human-induced pluripotent …
has completely altered the outlook for biomedical research. Human-induced pluripotent …
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
Tyrosine kinase inhibitors (TKIs), despite their efficacy as anticancer therapeutics, are
associated with cardiovascular side effects ranging from induced arrhythmias to heart …
associated with cardiovascular side effects ranging from induced arrhythmias to heart …
[HTML][HTML] Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform
C Denning, V Borgdorff, J Crutchley, KSA Firth… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
Dilated cardiomyopathy in the era of precision medicine: latest concepts and developments
Dilated cardiomyopathy (DCM) is an umbrella term entailing a wide variety of genetic and
non-genetic etiologies, leading to left ventricular systolic dysfunction and dilatation, not …
non-genetic etiologies, leading to left ventricular systolic dysfunction and dilatation, not …
Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine: a scientific statement from the American Heart Association
K Musunuru, F Sheikh, RM Gupta… - Circulation: Genomic …, 2018 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …
physiology and disease at the cellular level. They also have the potential to be leveraged in …
Miniaturized iPS-cell-derived cardiac muscles for physiologically relevant drug response analyses
Tissue engineering approaches have the potential to increase the physiologic relevance of
human iPS-derived cells, such as cardiomyocytes (iPS-CM). However, forming Engineered …
human iPS-derived cells, such as cardiomyocytes (iPS-CM). However, forming Engineered …
Patient-specific and genome-edited induced pluripotent stem cell–derived cardiomyocytes elucidate single-cell phenotype of Brugada syndrome
Abstract Background: Brugada syndrome (BrS), a disorder associated with characteristic
electrocardiogram precordial ST-segment elevation, predisposes afflicted patients to …
electrocardiogram precordial ST-segment elevation, predisposes afflicted patients to …
Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity
Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical
market. Several chemotherapeutic compounds have been noted for their propensities to …
market. Several chemotherapeutic compounds have been noted for their propensities to …