New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Early-onset Alzheimer disease and its variants
MF Mendez - CONTINUUM: Lifelong Learning in Neurology, 2019 - journals.lww.com
PURPOSE OF REVIEW Early-onset Alzheimer disease (AD) is defined as having an age of
onset younger than 65 years. While early-onset AD is often overshadowed by the more …
onset younger than 65 years. While early-onset AD is often overshadowed by the more …
Early-onset Alzheimer disease
MF Mendez - Neurologic clinics, 2017 - neurologic.theclinics.com
Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …
and did not include older patients with “senile dementia.” In fact, the first patient reported …
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
Background Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and
together with polygenetic risk stratification can contribute towards planning of feasible and …
together with polygenetic risk stratification can contribute towards planning of feasible and …
Biomarkers for Alzheimer's disease diagnosis
V Mantzavinos, A Alexiou - Current Alzheimer Research, 2017 - ingentaconnect.com
Objective: The dramatic increase in the population with dementia expected in the next
decades is accompanied by the establishment of novel and innovated methods that will offer …
decades is accompanied by the establishment of novel and innovated methods that will offer …
Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes
Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …
Genetics, functions, and clinical impact of presenilin-1 (PSEN1) gene
Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …
APP, PSEN1, and PSEN2 Variants in Alzheimer's Disease: Systematic Re-evaluation According to ACMG Guidelines
X **ao, H Liu, X Liu, W Zhang, S Zhang… - Frontiers in aging …, 2021 - frontiersin.org
The strategies of classifying APP, PSEN1, and PSEN2 variants varied substantially in the
previous studies. We aimed to re-evaluate these variants systematically according to the …
previous studies. We aimed to re-evaluate these variants systematically according to the …
Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls
C Bellenguez, C Charbonnier, B Grenier-Boley… - Neurobiology of …, 2017 - Elsevier
We performed whole-exome and whole-genome sequencing in 927 late-onset Alzheimer
disease (LOAD) cases, 852 early-onset AD (EOAD) cases, and 1273 controls from France …
disease (LOAD) cases, 852 early-onset AD (EOAD) cases, and 1273 controls from France …