Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Knee osteoarthritis: Current status and research progress in treatment

R Geng, J Li, C Yu, C Zhang… - Experimental and …, 2023 - spandidos-publications.com
Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It is also the
most common form of OA and is characterized by high morbidity and disability rates. With the …

Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019

H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …

Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

A Cui, H Li, D Wang, J Zhong, Y Chen, H Lu - EClinicalMedicine, 2020 - thelancet.com
Background Knee osteoarthritis (OA) is a major cause of disability in the elderly, however,
there are few studies to estimate the global prevalence, incidence, and risk factors of knee …

Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis

H Yu, Y Huang, L Yang - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), as a common orthopedic disease with cartilage injury as its main
pathological feature, has a complex pathogenesis and existing medical technology remains …

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to …

H Zhou, X Shen, C Yan, W **ong, Z Ma, Z Tan… - Stem Cell Research & …, 2022 - Springer
Background Osteoarthritis (OA) is a prevalent degenerative joint disease that not only
significantly impairs the quality of life of middle-aged and elderly individuals but also …

[HTML][HTML] Osteoarthritis year in review 2017: clinical

AE Nelson - Osteoarthritis and cartilage, 2018 - Elsevier
This review is based on a systematic review of the literature relevant to clinical topics in
osteoarthritis (OA) performed for the time period February 22, 2016 to April 1, 2017. A …

Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition)

Z Zhang, C Huang, Q Jiang, Y Zheng… - Annals of …, 2020 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is a degenerative disease of middle-aged and elderly people, contributed
a higher burden of disease in China and the world. In 2017, under the support of the …

Intra-articular nanodrug delivery strategies for treating osteoarthritis

D Zhou, F Zhou, S Sheng, Y Wei, X Chen, J Su - Drug discovery today, 2023 - Elsevier
Highlights•We categorize the challenges and corresponding solutions for nano-drug
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …

[HTML][HTML] Chronic disease in China: geographic and socioeconomic determinants among persons aged 60 and older

B Su, D Li, J **e, Y Wang, X Wu, J Li… - Journal of the American …, 2023 - Elsevier
Objectives This study aimed to reveal the epidemic characteristics of chronic diseases
among the Chinese older population and provide empirical strategies for the prevention and …