The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

K+ channel principal subunits are by far the largest and most diverse of the ion channels.
This diversity originates partly from the large number of genes coding for K+ channel …

The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox
transformations involved in biosynthesis, intermediary metabolism, and detoxification …

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to sha** the waveforms of action potentials, and several …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …

▪ Abstract Potassium channels contribute to the excitability of neurons and signaling in the
nervous system. They arise from multiple gene families including one for voltage-gated …

Recent advances in molecular biology have had a major impact on our understanding of the
biophysical and molecular properties of ion channels. This review is focused on cardiac …

Voltage-gated K+ channels are protein complexes composed of ion-conducting integral
membrane α subunits and cytoplasmic β subunits. Here, we show that, in transfected …

Prolongation of action potential duration is the most consistent electrophysiological
abnormality in myocardium and myocytes from hypertrophied and failing hearts …