Parkinson's disease
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
[HTML][HTML] Parkinson disease-associated cognitive impairment
Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting>
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …
Genetics and pathogenesis of Parkinson's syndrome
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Detection of neuron-derived pathological α-synuclein in blood
To date, no reliable clinically applicable biomarker has been established for Parkinson's
disease. Our results indicate that a long anticipated blood test for Parkinson's disease may …
disease. Our results indicate that a long anticipated blood test for Parkinson's disease may …
Periphery and brain, innate and adaptive immunity in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …
central role in the death and dysfunction of neurons, both, in central, as well as in the …
The gut–brain axis and its relation to Parkinson's disease: a review
EM Klann, U Dissanayake, A Gurrala… - Frontiers in aging …, 2022 - frontiersin.org
Parkinson's disease is a chronic neurodegenerative disease characterized by the
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …
was identified as an important player in a complex neurodegenerative disease that affects> …
Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions
A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …