During random locomotion, human neutrophils and Dictyostelium discoideum amoebae
repeatedly extend and retract cytoplasmic processes. During directed cell migration …

In macropinocytosis, cells take up micrometre-sized droplets of medium into internal
vesicles. These vesicles are acidified and fused to lysosomes, their contents digested and …

Current models of eukaryotic chemotaxis propose that directional sensing causes localized
generation of new pseudopods. However, quantitative analysis of pseudopod generation …

Macropinocytosis is a fundamental mechanism that allows cells to take up extracellular
liquid into large vesicles. It critically depends on the formation of a ring of protrusive actin …

Although directed migration of eukaryotic cells may have evolved to escape nutrient
depletion, it has been adopted for an extensive range of physiological events during …

Polarization, a primary step in the response of an individual eukaryotic cell to a spatial
stimulus, has attracted numerous theoretical treatments complementing experimental …

Cells have an internal compass that enables them to move along shallow chemical
gradients. As amoeboid cells migrate, signaling events such as Ras and PI3K activation …

It is generally believed that cytoskeletal activities drive random cell migration, whereas
signal transduction events initiated by receptors regulate the cytoskeleton to guide cells …

Newly generated actin free barbed ends at the front of motile cells provide sites for actin
filament assembly driving membrane protrusion. Growth factors induce a rapid biphasic …

Small GTPases are involved in the control of diverse cellular behaviours, including cellular
growth, differentiation and motility. In addition, recent studies have revealed new roles for …