Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Lung cancer is a main cause of death all over the world with a high incidence rate.
Metastasis into neighboring and distant tissues as well as resistance of cancer cells to …

Extracellular acidification is a well-known driver of tumorigenesis that has been extensively
studied. In contrast, the role of endosomal pH is novel and relatively unexplored. There is …

The five plasma membrane Na+/H+ exchanger (NHE) isoforms in the gastrointestinal tract
are characterized by distinct cellular localization, tissue distribution, inhibitor sensitivities …

Extracellular vesicles (EVs) are lipid membrane enclosed nano-sized vesicles that are
secreted by all known organisms. These vesicles are increasingly recognized as important …

Cancer drug resistance is one of the main barriers to overcome to ensure durable treatment
responses. While many pivotal advances have been made in first combination therapies …

Glioma accounts for approximately 80% of all malignant brain tumors. This study aimed to
investigate the interaction between specificity protein 1 (SP1) and NLR family pyrin domain …

Background Deregulation of long non-coding RNAs (lncRNAs) is frequently relevant to the
malignant phenotypical changes. This study aimed to explore the role of lncRNA GABPB1 …

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to
the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the …

Marizomib is a novel, irreversible, brain-penetrant pan-proteasome inhibitor with
encouraging findings in preclinical models and early-stage clinical trials for patients with …