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Interplay between NLRP3 inflammasome and autophagy
M Biasizzo, N Kopitar-Jerala - Frontiers in Immunology, 2020 - frontiersin.org
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
AIM2 in health and disease: Inflammasome and beyond
Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …
Autophagy and macrophage functions: inflammatory response and phagocytosis
MY Wu, JH Lu - Cells, 2019 - mdpi.com
Autophagy is a conserved bulk degradation and recycling process that plays important roles
in multiple biological functions, including inflammatory responses. As an important …
in multiple biological functions, including inflammatory responses. As an important …
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer
Y ** cellular immunity against HIV-1
M Colomer-Lluch, A Ruiz, A Moris… - Frontiers in …, 2018 - frontiersin.org
Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …
blocking viral replication and propagation. In addition to interfering at critical steps of the …
TRIM family contribute to tumorigenesis, cancer development, and drug resistance
N Huang, X Sun, P Li, X Liu, X Zhang, Q Chen… - … Hematology & Oncology, 2022 - Springer
The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …
The role of the NLRP3 inflammasome and programmed cell death in acute liver injury
C Yu, P Chen, L Miao, G Di - International Journal of Molecular Sciences, 2023 - mdpi.com
Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …
progresses to acute liver failure, seriously compromising the life safety of patients. The …
The first line of defence: insights into mechanisms and relevance of phagocytosis in epithelial cells
J Günther, HM Seyfert - Seminars in immunopathology, 2018 - Springer
Epithelial tissues cover most of the external and internal surfaces of the body and its organs.
Inevitably, these tissues serve as first line of defence against inorganic, organic, and …
Inevitably, these tissues serve as first line of defence against inorganic, organic, and …
TRIM21 promotes innate immune response to RNA viral infection through Lys27-linked polyubiquitination of MAVS
B Xue, H Li, M Guo, J Wang, Y Xu, X Zou… - Journal of …, 2018 - journals.asm.org
Human innate immunity responds to viral infection by activating the production of interferons
(IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a …
(IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a …
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy
The AIM2 inflammasome is a key cytosolic signaling complex that is activated by double-
stranded DNA, leading to the maturation of proinflammatory cytokines such as interleukin-1β …
stranded DNA, leading to the maturation of proinflammatory cytokines such as interleukin-1β …