Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs
Prodrug approaches represent an excellent solution to certain pharmaceutical issues
commonly encountered in the drug discovery and development process. Along this line, the …
commonly encountered in the drug discovery and development process. Along this line, the …
Strategies toward organic carbon monoxide prodrugs
Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …
Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide
Controlled activation is a critical component in prodrug development. Here we report a
concentration-sensitive platform approach for bioorthogonal prodrug activation by taking …
concentration-sensitive platform approach for bioorthogonal prodrug activation by taking …
Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …
with a variety of pathophysiological and pharmacological functions, including …
Role of carbon monoxide in host–gut microbiome communication
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
Click chemistry approaches for develo** carbonic anhydrase inhibitors and their applications
Click chemistry reactions constitute an important and relatively new approach in the
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …
Liposome surface modification by phospholipid chemical reactions
Liposomal systems are well known for playing an important role as drug carriers, presenting
several therapeutic applications in different sectors, such as in drug delivery, diagnosis, and …
several therapeutic applications in different sectors, such as in drug delivery, diagnosis, and …
[HTML][HTML] Nature's marvels endowed in gaseous molecules I: carbon monoxide and its physiological and therapeutic roles
Nature has endowed gaseous molecules such as O 2, CO 2, CO, NO, H 2 S, and N 2 with
critical and diverse roles in sustaining life, from supplying energy needed to power life and …
critical and diverse roles in sustaining life, from supplying energy needed to power life and …
Carbon monoxide: An emerging therapy for acute kidney injury
Treating acute kidney injury (AKI) represents an important unmet medical need both in terms
of the seriousness of this medical problem and the number of patients. There is also a large …
of the seriousness of this medical problem and the number of patients. There is also a large …
Organic CO prodrugs: Structure–CO‐release rate relationship studies
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and
may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A …
may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A …