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[HTML][HTML] Smouldering lesion in MS: microglia, lymphocytes and pathobiochemical mechanisms
Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …
Multiple sclerosis and cognition: synaptic failure and network dysfunction
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …
(MS), with important implications for the everyday life of individuals with MS and for disease …
Gut microbial factors predict disease severity in a mouse model of multiple sclerosis
A Steimle, M Neumann, ET Grant, S Willieme… - Nature …, 2024 - nature.com
Gut bacteria are linked to neurodegenerative diseases but the risk factors beyond microbiota
composition are limited. Here we used a pre-clinical model of multiple sclerosis (MS) …
composition are limited. Here we used a pre-clinical model of multiple sclerosis (MS) …
Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
A Gentile, A Musella, S Bullitta, D Fresegna… - Journal of …, 2016 - Springer
Background Data from multiple sclerosis (MS) and the MS rodent model, experimental
autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent …
autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent …
Correspondence among gray matter atrophy and atlas-based neurotransmitter maps is clinically relevant in multiple sclerosis
In multiple sclerosis (MS), gray matter (GM) atrophy progresses in a non-random manner,
possibly in regions with a high distribution of specific neurotransmitters involved in several …
possibly in regions with a high distribution of specific neurotransmitters involved in several …
Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition
M Dubey, M Pascual-Garcia, K Helmes, DD Wever… - elife, 2022 - elifesciences.org
Abstract Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically
involved in producing rapid network oscillations and cortical microcircuit computations, but …
involved in producing rapid network oscillations and cortical microcircuit computations, but …
Advances in brain imaging in multiple sclerosis
Brain imaging is increasingly used to support clinicians in diagnosing multiple sclerosis
(MS) and monitoring its progression. However, the role of magnetic resonance imaging …
(MS) and monitoring its progression. However, the role of magnetic resonance imaging …
Glia: a major player in glutamate–GABA dysregulation‐mediated neurodegeneration
The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …
Selective vulnerability of inhibitory networks in multiple sclerosis
In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system,
neurodegeneration is detected early in the disease course and is associated with the long …
neurodegeneration is detected early in the disease course and is associated with the long …
Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium
JA Van Winkle, ST Peterson, EA Kennedy… - elife, 2022 - elifesciences.org
Abstract Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric
viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that …
viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that …