[HTML][HTML] Smouldering lesion in MS: microglia, lymphocytes and pathobiochemical mechanisms

D Pukoli, L Vécsei - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Gut microbial factors predict disease severity in a mouse model of multiple sclerosis

A Steimle, M Neumann, ET Grant, S Willieme… - Nature …, 2024 - nature.com
Gut bacteria are linked to neurodegenerative diseases but the risk factors beyond microbiota
composition are limited. Here we used a pre-clinical model of multiple sclerosis (MS) …

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis

A Gentile, A Musella, S Bullitta, D Fresegna… - Journal of …, 2016 - Springer
Background Data from multiple sclerosis (MS) and the MS rodent model, experimental
autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent …

Correspondence among gray matter atrophy and atlas-based neurotransmitter maps is clinically relevant in multiple sclerosis

A Fiore, P Preziosa, N Tedone, M Margoni… - Molecular …, 2023 - nature.com
In multiple sclerosis (MS), gray matter (GM) atrophy progresses in a non-random manner,
possibly in regions with a high distribution of specific neurotransmitters involved in several …

Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition

M Dubey, M Pascual-Garcia, K Helmes, DD Wever… - elife, 2022 - elifesciences.org
Abstract Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically
involved in producing rapid network oscillations and cortical microcircuit computations, but …

Advances in brain imaging in multiple sclerosis

R Cortese, S Collorone, O Ciccarelli… - Therapeutic …, 2019 - journals.sagepub.com
Brain imaging is increasingly used to support clinicians in diagnosing multiple sclerosis
(MS) and monitoring its progression. However, the role of magnetic resonance imaging …

Glia: a major player in glutamate–GABA dysregulation‐mediated neurodegeneration

A Sood, K Preeti, V Fernandes… - Journal of …, 2021 - Wiley Online Library
The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …

Selective vulnerability of inhibitory networks in multiple sclerosis

L Zoupi, SA Booker, D Eigel, C Werner, PC Kind… - Acta …, 2021 - Springer
In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system,
neurodegeneration is detected early in the disease course and is associated with the long …

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

JA Van Winkle, ST Peterson, EA Kennedy… - elife, 2022 - elifesciences.org
Abstract Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric
viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that …