The β-and γ-secretase-driven cleavage of the amyloid precursor protein (APP) gives rise to
the amyloid β peptide, which is believed to be the main driver of neurodegeneration in …

As the global population ages, the incidence of elderly patients with dementia, represented
by Alzheimer's disease (AD), will continue to increase. Previous studies have suggested that …

Background Because of the increasing life expectancy in our society, aging-related
neurodegenerative disorders are one of the main issues in global health. Most of these …

Impaired activities and abnormally enlarged structures of endolysosomes are frequently
observed in Alzheimer disease (AD) brains. However, little is known about whether and how …

Objective: To study the effect of lncRNA WT1-AS on oxidative stress injury (OSI) and
apoptosis of neurons in Alzheimer's disease (AD) and its specific mechanisms related to the …

It has been demonstrated that peroxisome proliferator-activated receptor γ (PPARγ) can
regulate the transcription of its target gene, insulin-degrading enzyme (IDE), and thus …

White matter lesions (WML) emerge as a consequence of vascular injuries in the brain.
While they are commonly observed in aging, associations have been established with …

Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on
the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein …

Objective Current treatment and prognosis of Parkinson's disease (PD) are not ideal. This
study explored the mechanism of long non-coding RNA (lncRNA) rhabdomyosarcoma 2 …

Background: Emerging evidence demonstrates association of Alzheimer's disease (AD) with
impaired delivery of blood oxygen and nutrients to and throughout the brain. The cerebral …