Schizophrenia is frequently a chronic and disabling disorder, characterized by
heterogeneous positive and negative symptom constellations. The objective of this review …

The presence of depression in schizophrenia has been a challenge to the Kraepelinian
dichotomy, with various attempts to save the fundamental distinction including evoking and …

BackgroundDuring the last decades, a renewed interest for negative symptoms (NS) was
brought about by the increased awareness that they interfere severely with real-life …

The transdiagnostic expression of psychotic experiences in common mental disorder
(anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a …

The aim of this guidance paper of the European Psychiatric Association is to provide
evidence-based recommendations on the early detection of a clinical high risk (CHR) for …

Importance The ultra high-risk (UHR) criteria were introduced to prospectively identify
patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients …

Objective: Two-thirds of individuals identified as at ultra-high risk for psychosis do not
develop psychotic disorder over the medium term. The authors examined outcomes in a …

BackgroundThe nosology of the psychosis high-risk state is controversial. Traditionally
conceived as an 'at risk'state for the development of psychotic disorders, it is also …

Background: It is commonly assumed that there are clear lines of demarcation between
anxiety and depressive disorders on the one hand and psychosis on the other. Recent …

Motivational and hedonic impairments are core aspects of a variety of types of
psychopathology. These impairments cut across diagnostic categories and may be critical to …