Impact of epigenetic reprogramming on antitumor immune responses in glioma

BL McClellan, S Haase, FJ Nunez, MS Alghamri… - The Journal of clinical …, 2023 - jci.org
Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …

Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma

CJ Pachocki, EM Hol - Journal of Neuroinflammation, 2022 - Springer
Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …

[HTML][HTML] Microglia and brain macrophages as drivers of glioma progression

Y Zheng, MB Graeber - International Journal of Molecular Sciences, 2022 - mdpi.com
Evidence is accumulating that the tumour microenvironment (TME) has a key role in the
progression of gliomas. Non-neoplastic cells in addition to the tumour cells are therefore …

Nivolumab with or without ipilimumab in pediatric patients with high-grade CNS malignancies: safety, efficacy, biomarker, and pharmacokinetics—checkmate 908

IJ Dunkel, F Doz, NK Foreman, D Hargrave… - Neuro …, 2023 - academic.oup.com
Background Therapeutic options are limited in pediatric CNS malignancies. CheckMate 908
(NCT03130959) is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab …

Targeting enhancer of zeste homolog 2 for the treatment of hematological malignancies and solid tumors: candidate structure–activity relationships insights and …

J **a, J Li, L Tian, X Ren, C Liu… - Journal of Medicinal …, 2022 - ACS Publications
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that can change the
expression of downstream target genes by catalyzing the trimethylation of lysine 27 of …

[HTML][HTML] Therapeutic targets in diffuse midline gliomas—an emerging landscape

E Hayden, H Holliday, R Lehmann, A Khan, M Tsoli… - Cancers, 2021 - mdpi.com
Simple Summary Diffuse midline gliomas (DMGs) remain one of the most devastating
childhood brain tumour types, for which there is currently no known cure. In this review we …

The tumor micro-environment in pediatric glioma: friend or foe?

J Messiaen, SA Jacobs, F De Smet - Frontiers in Immunology, 2023 - frontiersin.org
Brain tumors are the leading cause of morbidity and mortality related to cancer in children,
where high-grade glioma harbor the worst prognosis. It has become obvious that pediatric …

Survival and neurological outcomes after stereotactic biopsy of diffuse intrinsic pontine glioma: a systematic review

M Dalmage, MA LoPresti, P Sarkar… - Journal of …, 2023 - thejns.org
OBJECTIVE Diffuse intrinsic pontine gliomas (DIPGs) are aggressive and malignant tumors
of the brainstem. Stereotactic biopsy can obtain molecular and genetic information for …

Targeting epigenetic mechanisms of resistance to chemotherapy in gliomas

P Skouras, M Markouli, I Papadatou, C Piperi - Critical Reviews in …, 2024 - Elsevier
Glioma, an aggressive type of brain tumors of glial origin is highly heterogeneous, posing
significant treatment challenges due to its intrinsic resistance to conventional therapeutic …

[HTML][HTML] The growing relevance of immunoregulation in pediatric brain tumors

V Melcher, K Kerl - Cancers, 2021 - mdpi.com
Simple Summary Pediatric brain tumors are the leading cause of childhood cancer-related
deaths worldwide. Considering the dismal prognosis and the adverse effects of chemo-and …