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Impact of epigenetic reprogramming on antitumor immune responses in glioma
Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …
Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma
CJ Pachocki, EM Hol - Journal of Neuroinflammation, 2022 - Springer
Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …
[HTML][HTML] Microglia and brain macrophages as drivers of glioma progression
Y Zheng, MB Graeber - International Journal of Molecular Sciences, 2022 - mdpi.com
Evidence is accumulating that the tumour microenvironment (TME) has a key role in the
progression of gliomas. Non-neoplastic cells in addition to the tumour cells are therefore …
progression of gliomas. Non-neoplastic cells in addition to the tumour cells are therefore …
Nivolumab with or without ipilimumab in pediatric patients with high-grade CNS malignancies: safety, efficacy, biomarker, and pharmacokinetics—checkmate 908
Background Therapeutic options are limited in pediatric CNS malignancies. CheckMate 908
(NCT03130959) is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab …
(NCT03130959) is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab …
Targeting enhancer of zeste homolog 2 for the treatment of hematological malignancies and solid tumors: candidate structure–activity relationships insights and …
J **a, J Li, L Tian, X Ren, C Liu… - Journal of Medicinal …, 2022 - ACS Publications
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that can change the
expression of downstream target genes by catalyzing the trimethylation of lysine 27 of …
expression of downstream target genes by catalyzing the trimethylation of lysine 27 of …
[HTML][HTML] Therapeutic targets in diffuse midline gliomas—an emerging landscape
E Hayden, H Holliday, R Lehmann, A Khan, M Tsoli… - Cancers, 2021 - mdpi.com
Simple Summary Diffuse midline gliomas (DMGs) remain one of the most devastating
childhood brain tumour types, for which there is currently no known cure. In this review we …
childhood brain tumour types, for which there is currently no known cure. In this review we …
The tumor micro-environment in pediatric glioma: friend or foe?
J Messiaen, SA Jacobs, F De Smet - Frontiers in Immunology, 2023 - frontiersin.org
Brain tumors are the leading cause of morbidity and mortality related to cancer in children,
where high-grade glioma harbor the worst prognosis. It has become obvious that pediatric …
where high-grade glioma harbor the worst prognosis. It has become obvious that pediatric …
Survival and neurological outcomes after stereotactic biopsy of diffuse intrinsic pontine glioma: a systematic review
OBJECTIVE Diffuse intrinsic pontine gliomas (DIPGs) are aggressive and malignant tumors
of the brainstem. Stereotactic biopsy can obtain molecular and genetic information for …
of the brainstem. Stereotactic biopsy can obtain molecular and genetic information for …
Targeting epigenetic mechanisms of resistance to chemotherapy in gliomas
Glioma, an aggressive type of brain tumors of glial origin is highly heterogeneous, posing
significant treatment challenges due to its intrinsic resistance to conventional therapeutic …
significant treatment challenges due to its intrinsic resistance to conventional therapeutic …
[HTML][HTML] The growing relevance of immunoregulation in pediatric brain tumors
V Melcher, K Kerl - Cancers, 2021 - mdpi.com
Simple Summary Pediatric brain tumors are the leading cause of childhood cancer-related
deaths worldwide. Considering the dismal prognosis and the adverse effects of chemo-and …
deaths worldwide. Considering the dismal prognosis and the adverse effects of chemo-and …