BACKGROUND Disorders of bone metabolism, most notably osteoporosis, are highly
prevalent and predispose to fractures, causing high patient morbidity and mortality …

Abstract Summary The International Osteoporosis Foundation (IOF) and the International
Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend that a marker …

Osteoporosis, a major public health problem, is becoming increasingly prevalent with the
aging of the world population. Osteoporosis is a skeletal disorder characterized by …

Abstract The International Osteoporosis Foundation (IOF) and the International Federation of
Clinical Chemistry and Laboratory Medicine (IFCC) Working Group on Bone Marker …

Biochemical markers of bone turnover (bone turnover markers, BTMs) can be used to study
changes in bone remodelling in osteoporosis. Investigators and clinicians should be aware …

The osteoblast‐derived protein osteocalcin has recently been shown to affect adiposity and
glucose homeostasis in mice, suggesting that the skeleton influences energy metabolism …

Tartrate-resistant acid phosphatase (TRACP) is an enzyme that is expressed in high
amounts by bone-resorbing osteoclasts, inflammatory macrophages and dendritic cells. Two …

The aim of this report was to summarize the clinical performance of two reference bone
turnover markers (BTMs) in the prediction of fracture risk. We used an updated systematic …

BACKGROUND There is currently no standard practice for the monitoring of patients
receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is …

Osteoporosis, the most common chronic metabolic bone disease, is characterized by low
bone mass and increased bone fragility. Nowadays more than 200 million individuals are …