Single-molecule magnetic tweezers deliver magnetic force and torque to single target
molecules, permitting the study of dynamic changes in biomolecular structures and their …

Magnetic force spectroscopy is a rapidly develo** single molecule technique that has
found numerous applications at the interface of physics and biology. Since the invention of …

The classical view of DNA posits that DNA must be stiff below the persistence length [< 150
base pairs (bp)], but recent studies addressing this have yielded contradictory results. We …

AAA+ unfoldases denature and translocate polypeptides into associated peptidases. We
report direct observations of mechanical, force-induced protein unfolding by the ClpX …

The application of three-dimensional DNA origami objects as rigid mechanical mediators or
force sensing elements requires detailed knowledge about their complex mechanical …

We report a chemically programmed design and the switching characteristics of a functional
metal–DNA-origami–polyoxometalate (POM) material obtained from the solution-processed …

The primary building block of the body is collagen, which is found in the extracellular matrix
and in many stress-bearing tissues such as tendon and cartilage. It provides elasticity and …

The last 15 years saw a dramatic increase in the number of published papers exposing
research related to the concept of protein disorder and a concomitant increase in the …

Actin cytoskeleton force generation, sensing, and adaptation are dictated by the bending
and twisting mechanics of filaments. Here, we use magnetic tweezers and microfluidics to …

The histone chaperone FACT (facilitates chromatin transcription) enhances transcription in
eukaryotic cells, targeting DNA-protein interactions. FACT, a heterodimer in humans …