Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by
intrapancreatic nerve endings during the preabsorptive and absorptive phases of feeding. In …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

Secretion of the peptide hormone insulin from pancreatic β cells constitutes an important
step in the regulation of body homeostasis. Insulin is stored in large dense core vesicles and …

Increases in glucose or fatty acids affect metabolism via changes in long-chain acyl-CoA
formation and chronically elevated fatty acids increase total cellular CoA. Understanding the …

Okazaki 444-8585, Japan abstract. Nucleobindin-2 (NUCB2)-derived nesfatin-1 located in
the brain has been implicated in the satiety and control of energy metabolism. Nesfatin-1 is …

Pancreatic β cell dysfunction is a key feature of type 2 diabetes, and novel regulators of
insulin secretion are desirable. Here, we report that succinate receptor 1 (SUCNR1) is …

A. Ca2/calmodulin-dependent protein kinases B. Cyclic nucleotide-dependent protein
kinases C. Ca2/phospholipid-dependent protein kinases D. Mitogen-activated protein …

Insulin secretion from pancreatic islet β-cells is a tightly regulated process, under the close
control of blood glucose concentrations, and several hormones and neurotransmitters …

Abstract Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical
activity. Changes of the membrane potential (V m) are regulated by metabolism-dependent …